startxref 0000015416 00000 n Immunotherapy medicines work by helping your immune system attack cancer cells. Side … Getting medical treatment right away may help keep these problems from becoming more serious. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with IMFINZI. Durvalumab (trade name Imfinzi) is an FDA-approved immunotherapy for cancer, developed by Medimmune/AstraZeneca. You are about to enter the IMFINZI.com site for healthcare professionals. Progression-Free Survival. Getting medical treatment right away may help keep these problems from becoming more serious. 0000004683 00000 n These side effects happen in between 1 and 10 out of every 100 people (1 to 10%). Research … Even though the side effects of chemotherapy tend to be more severe than those of targeted therapies or immunotherapy, it's important to note that the side effects people experience today differ tremendously than those experienced by patients in the past. Problems can also happen in other organs and tissues. 0000001396 00000 n In some people these side … Unresectable Stage 3 Non-Small Cell Lung Cancer. 246 39 0000002793 00000 n The many current and planned clinical trials testing its effectiveness are clear proof. 0000061297 00000 n 0000001096 00000 n What are non … Occasional side effects. %PDF-1.4 %���� IMFINZI may be used when your NSCLC has not spread outside your chest, cannot be removed by surgery, and has responded or stabilized with initial treatment with chemotherapy that contains platinum, given at the same time as radiation therapy. In unresectable Stage III NSCLC following chemoradiotherapy. You might have one or more of them. 0000023202 00000 n 0000013313 00000 n Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. %%EOF US-49425 Last Updated 2/21. Learn more about the basics of immunotherapy and its side effects. Because of this, the side effects tend to be less severe than with chemotherapy drugs. 0000061498 00000 n xref Side Effects of Cancer Treatment. They include: tooth or mouth infections including thrush (this looks like white patches in your mouth) the flu (influenza), symptoms include a sudden fever, feeling achy and very tired; night … We collect these anonymous answers to learn more about the issues facing survivors. Please click here for complete Prescribing Information, including Patient Information (Medication Guide). 0000004370 00000 n News Yale Researcher Wins NIH Merit Award, Supporting Immunotherapy Work News CAR T-cell Therapy Tecartus Granted FDA Approval for Mantle Cell Lymphoma News Phase 3 Trial Launched to Test Cabometyx-Tecentriq in Advanced Kidney Cancer News New Light-activated CAR T-cells May Help Reduce Therapy Side Effects Tell your doctor if you have any side effect that bothers you or that does not go away. Talk with your doctor about possible side effects for the immunotherapy recommended for you. 0000006278 00000 n 0000018082 00000 n IMFINZI is a prescription medicine used to treat adults with a type of lung cancer called small cell lung cancer (SCLC). h�b``e``�����}�A�X؀�&X10�s`@,"^:�j�L&v�hF�. Talk to your healthcare provider about birth control methods that you can use during this time. In a large clinical trial, the immunotherapy … These abnormal cells kill the normal cells of the body and disrupt the normal body functions. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include: Chest pain, irregular heartbeats, shortness of breath or swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs; double vision, blurry vision, sensitivity to light, eyepain, changes in eyesight; persistent or severe muscle pain or weakness, muscle cramps; and low red blood cells, bruising, Infusion reactions that can sometimes be severe or life-threatening. Not all anti-cancer or chemotherapy medications have long-term side effects, but several have been associated with memory difficulties (sometimes called "chemo brain"), heart problems, diabetes, numbness or tingling in hands and feet, fertility … Common side effects include skin reactions, flu-like symptoms, diarrhea, lung inflammation causing shortness of breath, and weight changes. 0000026658 00000 n Ask your healthcare provider or pharmacist for more information. Lung problems: cough, shortness of breath, and chest pain, Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; and severe stomach-area (abdomen) pain or tenderness, Liver problems: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach-area (abdomen), dark urine (tea colored), and bleeding or bruising more easily than normal, Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increase sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; and changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness, Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, and loss of appetite, Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in mouth or nose, throat, or genital area; fever or flu-like symptoms; swollen lymph nodes, Problems can also happen in other organs and tissues. {g ��h ���]\. 0000004596 00000 n Lung cancer is the number one cause of cancer deaths in both men and women in the U.S. and worldwide. trailer 0000016708 00000 n Serious side effects seem to happen more often with this drug than with the PD-1 and PD-L1 inhibitors. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include: Infusion reactions that can sometimes be severe or life-threatening. 0000001736 00000 n 0 IMFINZI may be used with the chemotherapy medicines etoposide and carboplatin or cisplatin as your first treatment when your SCLC has spread within your lungs or to other parts of the body (extensive-stage small cell lung cancer, or ES-SCLC). Call your doctor for medical advice about side effects. 0000010084 00000 n It is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody that blocks the interaction of programmed cell death ligand 1 (PD-L1) with the PD-1 (CD279). IMFINZI can cause serious side effects (see above): The most common side effects in people with non-small cell lung cancer (NSCLC) include cough, feeling tired, inflammation in the lungs, upper respiratory tract infections, shortness of breath, and rash. Learn how different types of immunotherapy work. are breastfeeding or plan to breastfeed. 0000005276 00000 n Before you receive IMFINZI, tell your healthcare provider about all of your medical conditions, including if you: Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ; Passive exposure to tobacco smoke (passive smoking) also can cause lung cancer in non-smokers.The two types of lung cancer… 0000011665 00000 n 0000061822 00000 n Clinical Trials Information. 0000005727 00000 n 0000016805 00000 n 0000014473 00000 n IMFINZI is a prescription medicine used to treat adults with a type of lung cancer called non-small cell lung cancer (NSCLC). Lung cancer may spread to the lymph nodes or other organs in the body that commonly include the … Keytruda (pembrolizumab) is an FDA-approved immunotherapy treatment for cancer. The information in this site is intended for US healthcare professionals only. Side Effects. 0000061660 00000 n IMFINZI can cause serious side effects (see above): The most common side effects in people with non-small cell lung cancer (NSCLC) include cough, feeling tired, inflammation in the lungs, upper respiratory tract infections, shortness of breath, and rash. Tell your healthcare provider about all the medicines you take, The most common side effects in people with non-small cell lung cancer (NSCLC), The most common side effects when used with other anticancer medicines with SCLC, have immune system problems such as Crohn's disease, ulcerative colitis, or lupus, have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic), have received radiation treatment to your chest area, have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome, are pregnant or plan to become pregnant. These problems can sometimes become severe or life-threatening and can lead to death. Like those drugs, this drug can cause the immune system to attack other parts of the body, which can lead to serious problems in the intestines, liver, hormone-making glands, nerves, skin, eyes, or other organs. Important Safety Information. Less common, but important side effects can include: Serotonin Syndrome : This medication can cause a high level of serotonin in your body, which in rare cases, can lead to serotonin syndrome. Immunotherapy is one of the most promising forms of lung cancer treatment to come along in decades. When these medicines are given together, drug-related side effects reported in clinical studies give the best estimate of what to expect. 1-year primary PFS analysis (14.5 months median follow-up): PFS was statistically significant 2,5 *. There are no contraindications for IMFINZI ® (durvalumab).. Immune-Mediated Adverse Reactions. Potential side effects may vary according to the type of immunomodulator—and what exactly it targets—and may also be influenced by the location and type of cancer as well as a patient’s overall health. 0000003387 00000 n ; Cigarette smoking is the principal risk factor for the development of lung cancer. ... A large clinical trial showed that adding the immunotherapy drug durvalumab (Imfinzi) to standard chemotherapy can prolong survival in some people with previously untreated advanced small cell lung cancer. 0000019042 00000 n Your healthcare provider may also need to delay or completely stop treatment with IMFINZI if you have severe side effects. The U.S. Food and Drug Administration (FDA) has approved Libtayo (cemiplimab-rwlc), making it the first immunotherapy for people with advanced basal cell carcinoma (BCC) — the most common form of skin cancer — who previously received or were ineligible for treatment with a hedgehog pathway … Molecular profiling, which identifies specific DNA mutations in tumor cells, can determine if a person has a treatable mutation and is a candidate for therapy. IMFINZI can harm your unborn baby. 0000061336 00000 n Durvalumab is known as a checkpoint … Median PFS: 16.8 months with IMFINZI … Do not breastfeed during treatment and for at least 3 months after the last dose of IMFINZI. 0000004484 00000 n Lung cancer is cancer that originates in the lung cells.. Cancer is an abnormal and uncontrolled growth of the cells in the body. Tell your doctor if you have any side effect that bothers you or that does not … Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). You may report side effects … These complications may happen if you underwent transplantation either before or after being treated with IMFINZI. These are not all the possible side effects of IMFINZI. 0000001577 00000 n 0000016953 00000 n “With the most common type of immunotherapy … Starting Jan. 1, if members use a provider in the Northwood network, their medical copayment, cost share, coinsurance or deductible won't … <<114C08965827F44D8C2321BEF96C6372>]/Prev 94198/XRefStm 1396>> These problems may happen anytime during treatment or even after your treatment has ended. These are not all of the signs and symptoms of immune system problems that can happen with IMFINZI. IMFINZI is a registered trademark of the AstraZeneca group of companies. Immune-mediated adverse … IMFINZI ® (durvalumab) demonstrated consistent results in median PFS in 1-year through 4-year analyses 1,2,5. OncoLink, the Web's first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials Lung Cancer Support and Resources. a type of lung cancer called non-small cell lung cancer (NSCLC), a type of lung cancer called small cell lung cancer (SCLC), with the chemotherapy medicines etoposide and carboplatin or cisplatin as your first treatment when your SCLC. The healthcare provider plan does not ask about late effects and allows you to remove side effects you believe are not relevant for this patient. Long-term side effects of anti-cancer medications are specific to each medication. The most common side effects in people with non-small cell lung cancer (NSCLC) include cough, feeling tired, inflammation in the lungs, upper respiratory tract infections, shortness of breath, and rash. Your healthcare provider will check you for these problems during your treatment with IMFINZI. However, much of the information may also apply to unapproved uses that are being studied. Learn … This change effects members as follows: Blue Cross commercial fully insured groups: For these groups and members, we're moving to one provider, Northwood, beginning Jan. 1, 2021. In clinical studies, often only the most severe side effects from RICE chemotherapy were reported and are shown here. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, and back or neck pain. Moderna announced positive interim results from a Phase 1 clinical trial (NCT04283461) testing its potential COVID-19 vaccine mRNA-1273.The trial, led by the National Institutes of Health, is testing three different doses of mRNA-1273 in healthy volunteers ages 18–55 for safety, immune response, and adverse effects… The patient plan will ask you about long term effects you are experiencing. 0000061984 00000 n 0000006527 00000 n Side Effects. Immunotherapy is an umbrella term for cancer treatments that harness your own immune system. 0000014896 00000 n IMFINZI is a medicine that may treat certain cancers by working with your immune system. Important immune-mediated adverse reactions listed under Warnings and Precautions may not include all possible severe and fatal immune-mediated reactions. The side effects of monoclonal antibody treatment depend on the drug’s purpose. You may report side effects related to AstraZeneca products by clicking here. 0000006953 00000 n For example, the side effects of monoclonal antibodies used for targeted therapy are not like those used for immunotherapy. You can have more than one of these problems at the same time. It is not known if IMFINZI is safe and effective in children. Welcome to Inspire’s Lung Cancer Survivors community offered in partnership with the American Lung Association.A lung cancer support group with over 90,000 members created for patients and caregivers living with lung cancer. Call your doctor for medical advice about side effects. This information is intended for US consumers only. possible side effects. All rights reserved. In a multi-drug regimen, each medication has unique side effects. ©2021 AstraZeneca. The side effects of immune checkpoint inhibitors may include side effects similar to an allergic reaction. IMFINZI can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work.
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