(2001). Strazzullo P, Iacone R, Siani A, et al. We report the association of a single heterozygous Gly to Ser missense mutation in the glucagon receptor gene with late-onset NIDDM. Nutrient consumption-dependent association of a glucagon-like peptide-1 receptor gene polymorphism with insulin secretion. The identification of … NIH Common … Cells were grown in HG-DMEM supplemented with 800 ug/mL hygromycin and geneticin. Res. Plays an important role in mediating the responses to fasting. Mice with congenital loss of the glucagon receptor gene (Gcgr −/− mice) remain normoglycemic in insulinopenic conditions, suggesting that unopposed glucagon action is the driving force for hyperglycemia in Type-1 Diabetes Mellitus (T1DM).However, chronic loss of GCGR results in a neomorphic phenotype that includes hormonal signals with hypoglycemic activity. No. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene Nat Med. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM). Glucagon receptors are mainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract. Genet. In a pooled set of French and Sardinian patients, the gly40-to-ser mutation showed association with NIDDM (chi square = 14.4, P = 0.0001). Go to UniProtKB: P59768. This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. Gene References into Functions: 3.0 A-resolution crystal structure of the full-length human glucagon receptor (GCGR) in complex with a glucagon analogue and partial agonist, NNC1702 PMID: 29300013; work toward the mapping of interactions between the polypeptide hormone glucagon and the glucagon receptor PMID: 28508109 Nishiya, Y., Daimon, M., Mizushiri, S. et al. G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Glucagon receptor gene (GCGR) sequencing revealed a heterozygous deletion, K349_G359del and 4 missense mutations. Yamato E, Ikegami H, Takekawa K, et al. Le récepteur du glucagon-like peptide-1 ou GLP-1r (en anglais glucagon-like peptide 1 receptor ou GLP1R) est un récepteur membranaire, c'est-à-dire une protéine de la famille des récepteurs couplés aux protéines G [1].Il est codé par le gène humain correspondant sur le chromosome 6 [2], [3 Sequence similarities. Preproglucagon in humans is encoded by the GCG gene.. Proglucagon is a precursor of glucagon, and several other components.It is generated in the alpha cells of the pancreas and in the intestinal L cells in the distal ileum and colon. Otc spf-ash and wild-type (WT) mice placed on a high-protein diet on day 0 and administered weekly with α-GCGR or control antibodies for 39 days from day 2 (10 mg/kg; n = 6 per group). We assessed the impact of low blood glucose on the vision of C57BL/6J mice rendered hypoglycemic by a null mutation of the glucagon receptor gene, Gcgr. Genomics 20: 327–328 PubMed CrossRef Google Scholar. (1997). Proglucagon is a protein that is cleaved from preproglucagon. This cell line can be used to screen compounds that target the glucagon receptor. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Regulates the rate of hepatic glucose producti A single heterozygous missense mutation in exon 2 of the glucagon receptor gene that changes a glycine to a serine (Gly 40 Ser) has been found to be associated with type 2 diabetes in some French populations. We also observed an alternative splicing involving the 166-base pair exon. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. GCG (Glucagon) is a Protein Coding gene. Hager et al. The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors, coupled to G alpha i, G s and to a lesser extent G alpha q. Stimulation of the receptor results in the activation of adenylate cyclase and phospholipase C and in increased levels of the secondary messengers intracellular cAMP and calcium. Glucagon Receptor Related Products (62): By Effects: Inhibitors (3) Agonists (23) Antagonists (13) Modulators (1) Cat. Glucagon-like peptide-1 receptor is similar to these genes: Chromogranin A, CHRNB4, CHRNB2 and more. METHODS: The glucagon receptor (GCGR) gene and the glucagon gene were sequenced in a patient with hyperglucagonemia and pancreatic alpha cell hyperplasia without glucagonoma syndrome. 1996 Nov;2(11):1254-8. doi: 10.1038/nm1196-1254. When activated by glucagon, it increases hepatic glucose production. G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1).. Horm. Activation of the glucagon receptor results in adenylate cyclase-mediated cAMP formation. The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. [provided by RefSeq, Jan 2010] Organism: human (Homo sapiens) GCGR related publications. Diseases associated with GCG include Dumping Syndrome and Hyperglycemia.Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. GLP-1R single nucleotide polymorphism (SNP) is related to its activity, but the relationship between GLP-1R SNP and … GCGR (glucagon receptor) Identity: Alias (NCBI) GGR: GL-R: HGNC (Hugo) GCGR: HGNC Alias symb: GGR: LocusID (NCBI) 2642: Atlas_Id: 52502: Location: 17q25.3 [Link to chromosome band 17q25] Location_base_pair: Starts at 81804150 and ends at 81814008 bp from pter ( according to hg38-Dec_2013) Fusion genes (updated 2017) Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, … Authors L A Scrocchi 1 , T J Brown, N MaClusky, P L Brubaker, A B Auerbach, A L Joyner, D … Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists are able to inhibit bone resorption to a certain extent and improve bone formation. We cloned the 5′ upstream region of the rat glucagon receptor gene, demonstrating that the 5′ noncoding domain of the glucagon receptor mRNA contained two untranslated exons of 131 and 166 nucleotides (nt), respectively, separated by two introns of 0.6 and 3.2 kilobase pairs. Sloop and other antisense oligonucleotides (ASO) blocking glucagon receptors were used to treat type 2 diabetic animals. Potential projects encompass GLP-1, GLP-2 and GIP. Wide variety of Top suppliers High-quality customer support. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene. Glucagon receptor activity Specific Function This is a receptor for glucagon-like peptide 2. Gene Name GLP2R Uniprot ID O95838 Uniprot Name Glucagon-like peptide 2 receptor Molecular Weight 63000.84 Da This case may potentially represent a progenitor stage of glucagon cell adenomatosis with hyperglucagonemia in the absence of glucagonoma syndrome. cAMP accumulation activates cAMP-responsible-binding-protein (CREB), inducing transcription of carnitine acyl transferase-1 (CPT-1) and other genes required for beta-oxidation. The glucagon-like peptide-1 receptor (GLP1R) is a receptor protein found on beta cells of the pancreas and on neurons of the brain.It is involved in the control of blood sugar level by enhancing insulin secretion. In humans, the glucagon receptor is encoded by the GCGR gene. GLUCAGON SIGNALING PATHWAY (PW:0000676) View Ontology Report Description: In the pancreatic alpha cells of the islets of Langerhans, glucagon is processed from the precursor proglucagon by the prohormone convertase 2 (PC-2). GCGR: glucagon receptor GGR, GL-R Summary. Glucagon receptor polymorphisms, principally a Gly to Ser missense mutation in exon 2 at amino acid 40, have been observed with higher frequency in some but not all diabetic populations ((Analysis of the Gly40Ser polymorphism in the glucagon receptor gene in a German non-insulin-dependent diabetes mellitus population. and RET signaling.Gene Ontology (GO) annotations related to this gene include identical protein binding and hormone activity. Scrocchi, L., Brown, T., Maclusky, N. et al. RESULTS: The glucagon gene sequence was normal, but the GCGR … Metab. Glucagon receptor gene mutation in essential hypertension.. Nat. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Menzel S, Stoffel M, Espinosa R III, Fernald AA, Le Beau MM, Bell GI (1994) Localization of the glucagon receptor gene to human chromosome band 17q25. (1995) reported the association of a single heterozygous gly40-to-ser (G40S) mutation in the glucagon receptor gene with late-onset noninsulin-dependent diabetes mellitus (NIDDM; 125853). An opportunity exists for postdoctoral research fellowship studied in the broad area of glucagon-like peptides, with a potential focus on mechanisms of action in 1) the immune system 2) gut-brain communication, and 3) neurodegenerative disorders. Production Details HEK293 cells expressing human glucagon receptor were transfected with pHTS-Cre plasmid. Enhanced green fluorescent protein-conjugated wild type (WT) and mutant GCGR were used to characterize the functions of the mutant GCGR. Compare & Order Glucagon Receptor plasmids, CDNA clones, ORF clones and more genomics products. 12 (2): 122. It is also cleaved into the following components in different organs: Objective. In humans it is synthesised by the gene GLP1R, which is present on chromosome 6.It is a member of the glucagon receptor family of G protein-coupled receptors. Receptor gene expression inhibitors: the principle of action of these drugs is to block the expression of glucagon target receptor gene and reduce the expression of glucagon receptor mRNA, thereby achieving the role of treating diabetes. Liver ribonucleic acid (RNA) sequencing demonstrates glucagon receptor (GCGR) antibody-regulated expression of key genes involved in glutamine/glutamate/ammonia metabolism. The mutant receptor was shown to have a reduced affinity to bind to glucagon and to produce cAMP in response to glucagon stimulation . Using cryo-electron microscopy, we determined the structures of the human glucagon receptor ... Gene Names: GNG2: Membrane protein Mpstruc: Group: TRANSMEMBRANE PROTEINS: ALPHA-HELICAL: Sub Group: G Protein-Coupled Receptors: Class B1: Protein: glucagon receptor (GCGR) in complex with G s: Find proteins for P59768 (Homo sapiens) Explore P59768 . Glucagon receptor gene mutation in essential hypertension. 29 (2): 56-9. “Glucagon receptor (GcgR) antagonists include small-molecule inhibitors and humanized antibodies which antagonize glucagon receptor activation,” they …
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